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Similar observations have been reported in other cancer types, strongly supporting that critical phenotypic alterations in TAFs are maintained through epigenetic mechanisms (3, 8, 9).
Three PcNLP genes (PcNLP2, PcNLP6, PcNLP14) showing high expression during P. capsici infection were more down-regulated than other tested genes showing lower expression levels, strongly supporting that highly expressed genes are easier to suppress [ 62].
Among the dark-regulated genes, 1,618 (about 88%%) significantly changed their expression patterns after treatment with DCMU or DBMIB, strongly supporting that most of the dark-regulated transcriptional changes are a result of inhibition of photosynthesis (see Additional file 6: Figure S5A).
Syed et al. demonstrated that ectopic expression of Snk/ PLK2 in BL cells results in apoptosis and loss of Snk/ PLK2 expression was one of the most common events in B-cell neoplasia, strongly supporting that PLK2 is a human tumor suppressor gene [ 40].
Surprisingly, we found that H3K9ac-mintbody-GFP was immunoprecipitated only using anti-mouse IgG antibody (Supplementary Fig. S1), strongly supporting that H3K9ac-mintbody-GFP was properly folded and functional as an antibody in plant cells.
Moreover, adsorption isotherm data of Ni2+ on nanohybrid was well fit with the Langmuir adsorption isotherm, strongly supporting that the adsorption process was mainly monolayer on homogeneous adsorbent surfaces.
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