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As the median survival in our cohort was 8.8 years, with the majority of tumours being well differentiated and early stage, we hypothesise that the stage and grade distribution of our cohort may not be adequate to detect a prognostic role for VEGF-A, whose expression seems to be strongly stage and grade-dependant.
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The "miscellaneous" category also contains members of additional structural protein families many of whose members are strongly stage-regulated.
This strategy therefore revealed only the most strongly stage-specifically regulated genes; maximal differences of RNA expression values of 54-fold (ORF TGME49_295662, merozoite-specific) and 404-fold (ORF TGME49_215980, tachyzoite-specific) were measured.
Mortality of transgenics in the absence of tetracycline is strongly stage-specific, being primarily around the pupal stage (L4-pupae and pupae-adult; most affected individuals started to pupate but failed to develop beyond the earliest stages of pupal development).
We found a substantial TIF-to-plasma ratio that correlated strongly with stage, yet decreasing in advanced stage tumors.
Prognosis and treatment depend very strongly on stage and site of the disease.
The long-term survival of ovarian cancer patients correlates strongly with stage at diagnosis.
Pavey et al. [7] and Maeda et al. [21] found that plasma fibrinogen was associated with decreased survival and strongly with stage in 166 patients who underwent surgical resection of NSCLC.
As surgical debulking is strongly associated with stage these results may indicate an association with stage rather than surgical outcome.
Prognosis strongly varied by stage, with age-adjusted 5-year RS reaching 91.2% for localized stage, 50.5% for regional stage, and 19.8% for distant stage.
Interestingly, we observed XIAP to be strongly expressed in Stage III colorectal cancer, with weak staining in only 4% tumours compared to 17% in Stage II patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com