Sentence examples for strongly repressive from inspiring English sources

The persistence of a strongly repressive chromatin structure towards the telomere is consistent with the continuous spread of silencing at truncated telomeres [ 16].

Lamina-associated domains represent a strongly repressive chromatin environment enriched by H3K9me2, H3K9me3 and H3K27me3, and restrict movement and expression of genes nearby (Guelen et al., 2008; Peric-Hupkes et al., 2010; Wen et al., 2009).

In these Lamina Associated Domains (LADs) gene expression is strongly repressed, RNA Polymerase II (RNApolII) and active histone marks are depleted, and repressive histone marks are enriched.

These results indicate that in normal and malignant ovarian epithelial cells, repressive histone methylations (H3K27me3, H3K9me2 and H4K20me3) in the CLDN4 promoter, together with DNA hypermethylation, strongly repress CLDN4, whereas activating histone marks (H3K4me3 and H4Ac), in conjunction with DNA hypomethylation, allow CLDN4 transcriptionally permissive.

Finally, cluster 4 transcripts were strongly enriched for Polycomb repressive complex 2 binding across many cell types.

By this, they strongly influence the expression of polycomb repressive complex 2 (PRC2) target genes [ 27], and EZH2 inhibitors have been successfully used in tumors with these mutations [ 27, 28].

The chromodomain of the Drosophila PC protein from the PC repressive complex 1 (PRC1) binds to the H3 tail peptide trimethylated at K9 and more strongly at K27me2/3.

Compared with dating, calling sounds unbearably repressive.

Chartist riots merely led to repressive policing.

However, their regime was never completely repressive.

Polycomb repressive complex 2 (PRC2) is a chief epigenetic regulator.