Sentence examples for strongly rectifying from inspiring English sources
Furthermore, because TRPML currents are strongly rectifying at the inward direction, cellular cues can also regulate TRPML-mediated Ca2+ release by modulating lysosomal ∆ψ a driving force for Ca2+ release (Cheng et al., 2010; Dong et al., 2010a, b).
This model not only fully accounts for the cv profiles, but also explains the observed strongly rectifying current-voltage (i-V) behavior, in the cathodic and anodic regions.
This implies that CLC-5 is very strongly rectifying under these conditions where it only conducts outward currents and the Cl−/H+ exchange mechanism cannot be driven in the opposite direction.
The shape of the current/voltage relationship for SK3 channels is strongly inwardly rectifying (Grunnet et al, 2001).
However, adenosine at 10 4 and 10 3 M did open a novel strongly outwardly rectifying current (Fig. 2A).
In vivo current, generated by TRPM7 channels, is strongly outwardly rectifying, due to a blockage by cytosolic Mg2+ and, possibly, some additional internal factor [ 213].
The human CLC-5 is an electrogenic voltage-dependent 2Cl−/1H+ exchanger that gives rise to strongly outwardly rectifying currents when expressed.
However, the activation properties differ somewhat to the CLC Cl− channels: activation is strongly outwardly rectifying with no detectable currents at negative potentials (2, 22) and lowering extracellular pH reduces CLC-5 currents (2).
In the absence of any divalent cations in the bath solution, e.g. with the current carried by Na+, large and strongly inward rectifying currents were measured which reversed close to 0 mV.
Substitution of external Na+ for NMDG+ strongly augmented the outwardly rectifying current, an observation consistent with increased activity of reversed NCXpm.
When NAGly (10 μM) was applied to histamine-stimulated cells without prior exposure to Na+-free solution, it abolished the outwardly rectifying current stimulated by histamine and strongly suppressed basal NCXpm currents.
