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Compound is considered strongly potent when IC50 is lower than 1 μg/mL; moderate if IC50 ranges from 1 μg/mL to 10 μg/mL; and weak for IC50 higher than 10 μg/mL.
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A summary of previous reports on toxin accumulation and human incidents is presented to highlight the seafood species of higher risk to consumers, including crustaceans that are not listed in the EU directives for toxins monitoring and should be strongly considered as potent vectors of biotoxins to humans.
These findings strongly suggest that potent anti-tumoral effects of cinnamon extract are mediated by multiple action mechanisms.
Thus, these results strongly argue for potent proapoptotic cooperation between GSIXII and ABT-737 in breast cancer cells maintained in their microenvironment.
Finally, these studies strongly suggest that potent, rationally designed PMPMEase inhibitors would be invaluable therapeutic agents in the management of those colorectal cancers cases in which PMPMEase expression and activities are elevated.
Results obtained with mice do not necessarily translate to humans; nevertheless, data presented here strongly suggest that potent influenza A virus-specific CD8+ T cell responses cause fatal immunopathology in aged mice.
We observed that the levels of IL-33 mRNA and protein in LPS-stimulated macrophages were strongly suppressed by a potent HO-1 inducer, CoPP, treatment.
We have shown previously that epicutaneous immunization on barrier-disrupted skin induces potent and strongly Th2-biased immunity [1], [6].
To establish whether anthrax toxins were responsible for the downregulation of IL-8, the most potent and strongly affected neutrophil chemokine, we utilized isogenic mutants that specifically lacked LF (ΔLF), EF (ΔEF) or both anthrax toxins (ΔLF/EF).
As the concentration of BSA used in these studies was orders of magnitude greater than the tested PLUNC concentrations, this strongly argues for a potent and specific surfactant activity by the PLUNC protein.
These latter results strongly argue that the potent cell-death effect of GSIXII relies on the inhibition of Notch processing into its active form.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com