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PNPLA3 expression is very low in a fasted state, and is strongly induced with feeding.
The gluconeogenic gene FBP1, encoding fructose-1,6-bisphosphatase, was strongly induced with xylose.
When pupae were infected, most genes were strongly induced, with obvious differences in degree (Fig. 4).
The experiments reported above were carried out under conditions in which the expression of the β-globin genes was strongly induced with 400 µM CuSO4.
Vascular endothelial growth factor receptor-2 (VEGFR2 or FLK1) was strongly induced with exogenous OLFM1 whereas VEGFR1 (or FLT1) decreased.
Of equal interest are the species strongly induced with both methods of differentiation, which include SFRP4, PITX2 and WNT2B.
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However, PdigCHSII was strongly induced coincident with conidial production, suggesting a role in conidiogenesis.
Microarray and proteomic studies revealed that SnTox3 strongly induced responses consistent with those previously associated with classical host defence pathways including the expression of pathogenicity-related proteins and the induction of cell death.
H2O2 production by blood leukocytes was strongly induced after stimulation with PMA, but not after stimulation with bacteria.
Indeed, two putative PTSs (phosphotransferase systems) operon genes, strongly induced by cellobiose with functions connected to cellobiose metabolism, were reported by Servinsky et al. (2010), suggesting that C. acetobutylicum displays multiple mechanisms to import, phosphorylate and hydrolyse B-glucosides for entry into glycolyse.
In contrast, TGF-βRII mRNA expression was strongly induced by radiation with a biphasic profile (peak at 6 hours, over 20 fold induction, and increase again at 96 hours, ∼8 fold induction) (Figure S4b).
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