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The cleavable bond is located between P1 and P1', P1 being the strongest specificity determinant in the majority of the cases.
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TSG hypermethylation in cancer cells has strong specificity with respect to the tissue of origin and tumor-type-specific methylation patterns have been reported for primary human tumors and cancer cell lines [ 7- 11].
PCR-based methods are considered highly sensitive and also to demonstrate strong specificity via the design of primers that detect mRNA expression of tumor-specific genes such as cytokeratin (CK -20, uroplakin (UP) II, and epidermal growth faCK -20eceptor (EGFR) [ 13, 14].
They showed a strong specificity of tumour accumulation.
With these caveats in mind, we show that Napsin A exhibits strong specificity for ADCs of the lung origin.
The fabricated APOE4 electrochemical immunosensor exhibits strong specificity, high sensitivity, low detection limit and wide linear range.
They will allow good control effect on pests, safe to human and other beneficial animals and causes no pollution because they have strong specificity.
These results demonstrate the strong specificity of DNA targeting through the CD44 receptor using HA of high molecular weight as a ligand.
Our investigations revealed that the new optical probes QE and bivQ were feasible for high-contrast imaging of CCK2R-expressing xenografts in mice and showed a strong specificity of tumour accumulation.
Among five mutant enzymes tested, two showed strong specificity to 1-OH, one showed moderate preference to 1-OH, one preferred 3-OH, and one showed broad specificity towards 1-, 3-, 4- and 6-OH.
In order to analyze glycan structures, we performed ELLA on the soluble SOM for the first time and found that it exhibits strong specificity to Datura stramonium lectin (DSL).
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