Exact(11)
Notably, the degree of STAT1 repression varied between DLD-1 and HCT116 cells, with the strongest repression of STAT1 observed in DLD-1 cells.
The transcription factor reporters showing the strongest repression were selected and named synARA and synCRP.
Interestingly, the combined expression of MYC and mutant RAS led to the strongest repression of p16 and p21, which could explain the superior tumorigenicity of this oncogene combination.
The strongest repression of the unmethylated 5ʹUTR promoter activity was observed when DEAF1 was overexpressed, with the T allele preferentially repressed (Fig. 6c).
These results agree with bioinformatic predictions since the miRNAs with best-supported predictions (miR-124 and miR-135a) were found to cause the strongest repression.
The strongest repression was observed for CARP3 (to 5%), whereas only a 2- to 3-fold reduction of CARP1, CARP2, or CARP4 protein levels was detected.
Similar(48)
Although creA-mediated CCR in A. nidulans has largely been studied with respect to glucose as the repressing carbon source, phenotype tests indicated that acetate can also lead to strong repression.
"We live our whole lives under very, very, very strong repression.
Rohmer's films are the embodiment of terrifyingly strong passions and of equally terrifying, and slightly stronger, repression.
Our data suggest that strong repression of PIN4/PIN7 and transient PIN3 expression limit auxin redistribution in young LR columella cells.
"All I wanted was freedom, because my life had always been under these circumstances of strong repression and pressure," he says.
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