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Computational modelling was used to screen a monomer library in order to select the monomers able to form the strongest complex with the target analyte.
The most efficient host was the positively charged octakis[6- 2-aminoethylthio -6-deoxy]-γ-CD (γCys) that foctakis[6- 2-aminoethylthio -6-deoxy]-γ-CD (Kb ∼1700 M−1) in an enthalpically and entroctakis[6- 2-aminoethylthio -6-deoxy]-γ-CD/moctakis[6- 2-aminoethylthio -6-deoxy]-γ-CD
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On the other hand, in environments in which proton competition is absent, coordination will dominate, with the most basic donor atoms forming the strongest complexes with Fe(III PPIX.
All the analogues were found to form strong complex with hematin and inhibit the β-hematin formation in vitro.
ACBD3 (acyl-CoA-binding domain-containing protein-3) was recently shown to form a strong complex with PI4KB, activating its lipid kinase activity13,21.
Further, these analogues were found to form a strong complex with hematin and inhibit the β-hematin formation, therefore these compounds act via heme polymerization target.
The ability of avidin (Avn) to form strong complex with biotin (Btn) is frequently used in the detection and isolation of biomolecules in biochemical, analytical, and medicinal research.
Aluminum (Al) minerals form a strong complex with organic matter (OM) in soil, affecting the stability and degradability of OM and carbon (C) dynamics in soil.
Since the discovery that starch binds tri- and polyiodide and forms a strong complex with amylose, this method was used as "amylose indicator", to quantify amylose content in starch.
However, as an effect of avidity, its interaction with Aβ-oligomers results in a strong complex with an exceptionally slow off-rate.
As shown in Figure 4D, probe #1 formed a strong complex with SALL4B nuclear extract (lane 2), and the binding was completely ablated with unlabelled oligonucleotide probe #1 (lane 3).
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