More interestingly, the 80 nm anionic lipid particles were the most efficient antigen carrier for eliciting higher humoral immune response, as well as cellular immune response characterized by a strong secretion of gamma interferon (IFN-γ).
Those authors described a strong secretion by the C17.2 cells of the growth factors NGF, BDNF, and GDNF as the reason for their observation of axonal sprouting of endogenous cells and of the clear outcome improvement [39].
Identification of the genes involved indicated strong secretion stress in the secretion strain and to a lesser extent also in intracellular production.
SIX8 is part of a cluster with a strong secretion signal and a significantly higher percentage of aliphatic amino acids than the background distribution for all clusters.
BMDC that were serum starved in the presence of apo-SAA showed a strong secretion of IL-6, TNF- α, and IL-1 β after 24 h.
Hence, severe mis-sorting and strong secretion of vacuolar hydrolases might alternatively explain the failure of ESCRT mutants to recycle amino acids, maintain protein synthesis and boost the catabolic activity of vacuoles.
Pam or pIC-stimulated DC secreted low amounts of IL-6, TNFα, IL-10 and IL-12 whereas LPS or PGN-activated DC showed strong secretions of cytokines especially IL-6 and IL-12 (figure 1D, E).
