We have, however, optimized optokindling using a stronger induction protocol to elicit seizures in <5 days (McFarlan et al., CAN 2018 poster 1-G-144 1-G-144 1-G-144
Analysis of brown differentiation marker genes (for example, UCP1, PGC-1α, COXIV and Glut1) indicated that GW9508 triggered a stronger induction compared with ITA (Fig. 5b).
These compounds display significantly stronger induction of expression of BCL6-repressed genes and anti-proliferative effects than compounds that merely inhibit co-repressor interactions.
Indeed, GW9508 treatment of differentiated beige adipocytes for 24 h triggered a moderate but significant upregulation of thermogenic marker genes (UCP1 and PGC-1α), and a stronger induction of FGF21 expression (Fig. 6e) and release (Fig. 6f).
After inoculation with RS105, most of the genes with up-regulated expression were commonly stimulated in the wild type and OE lines, with stronger induction in the OE lines than in wild type.
It can be noted that si-LRF was less efficient than miR-20a despite the stronger induction of p19ARF.
The PBM exposed to F.n. for the full 24 hours showed a stronger induction in miR-155 than those exposed for only 2 hours (Figure 3B).
Increasing doses of zebrafish hjv were associated with stronger induction of the human hepcidin promoter, which was potentiated by the addition of BMP6 (Figure 5G).
It is conceivable that the stronger induction associated with the AML than with the ESFT fusion is a reflection of the higher expression level of the AML fusion protein that appears to be tolerated in MPCs.
This was confirmed in the HCT116 p53+/+ and HCT116 p53−/− cell lines, where we also observed a stronger induction of Fas mRNA by oxaliplatin treatment, mainly in the HCT116 p53-null cells (Figure 5D).
Stronger induction occurred in plants treated with JA.
