Sentence examples for stronger checkpoint from inspiring English sources

We propose that Exo1 subsequently generates ssDNA >5 kb from the chromosome end, leading to stronger checkpoint activation that is sufficient to arrest all cells with uncapped telomeres.

We thus conclude that replication in the presence of a DSB induces a substantially stronger checkpoint response than that observed in either G1 or G2/M phase.

This difference most likely reflects the fact that cdc13-1 mrc1Δ exo1Δ mutants have more severe telomere capping defect than cdc13-1 exo1Δ mutands and therefore activate a stronger checkpoint signal.

I don't think the quota is the right solution to handle the refugee crisis because I think a strong checkpoint is needed at the borders.

Both dosages induced a strong checkpoint signaling response as evidenced by phosphorylation of ATM and its target proteins.

Cell cycle progression is strictly controlled by a strong checkpoint system that arrests progression of the cell cycle until either DNA replication is completed or DNA damage is repaired [51].

Many kinetochore mutants provoke a strong checkpoint arrest (e.g., cse4-1, scmif2-3mif2-3, ame1-4, okp1-5, nnf1-17, mtw1-1, stu2-277, dam1-1) but a subset does not (e.g., ndc10-1, cep3-1, spc25-7, ndespite deseveresevere defects in chromosome-MT binding.

Expression of BubR1B1 loop did not overtly affect the kinetochore levels of endogenous Bub1, suggesting that the multiple MELTP sequences of Knl1 are not saturated with endogenous Bub1 even in the strong checkpoint-activating conditions of our assay.

Moreover, those cells displayed stronger DNA damage checkpoint activity: cell cycle arrest in G1/S phase in Cul4a-deficient MEFs lasted approximately 4 6 h longer than wild-type MEFs following UV damage.

It seems likely that stronger interference with checkpoint-dependent de-repression of MBF transcription would be required to establish its importance.

Bio-X affiliates Connie Weyand and Jorg Goronzy have discovered that in giant cell arteritis, in which the immune system attacks the aorta, the immune response is too strong because an immune checkpoint isn't braking hard enough.