P2, P3, P4 and P5 induced strong cell proliferation and secretion of both Th1 (INF-γ, IL-2) and Th2 (IL-4, IL-5) cytokines.
Surprisingly, strong T cell proliferation also was observed by day 6 in response to MDDC that had been stimulated with virus prior to co-culture in the presence of SEB (86.3%, 90%, and 80.3% for rHRSV, UV-rHRSV, and IAV, respectively).
However, RNAi silencing of α-spec or β-spec does produce a strong stem cell proliferation response, similar to overexpression of Yki (Fig 7D G).
In tumours with more Cx32-positive cells, the remaining β-catenin-positive cells might receive stronger growth-restricting signals from surrounding cells, possibly leading to a stronger inhibition of cell proliferation.
The combination of imatinib and radiotherapy showed a significantly stronger inhibition of cell proliferation compared to single radiotherapy.
We expect that a knockdown of all three members of AKT would lead to an even stronger effect on cell proliferation [ 27].
Combining imatinib treatment with radiotherapy showed a significantly stronger inhibition of cell proliferation compared to radiotherapy alone in a mouse model for breast cancer [ 221].
Nevertheless, the SFV vector provoked a stronger inhibition of cell proliferation than the SIN vector in 4 T1 cells, as demonstrated by the MTT cell viability assays performed over the 5 days following infection.
IGF1 is the major mediator of growth hormone effects; it thus has a strong influence on cell proliferation and differentiation and is a potent inhibitor of apoptosis (Furstenberger and Senn 2002).
Pharmacological inhibition of IMPDH induced a moderate reduction of cell viability and a strong decrease of cell proliferation, but no increase in chemosensitivity.
