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A third novel quality control system has been identified for yeast mRNAs with defects in translation elongation due to strong translation pause sites.
The basic idea is that we first generate an ensemble of weak translation systems using a base learning algorithm, and then learn a strong translation system from the ensemble.
We demonstrated that TISU, which has an invariable ATG, composes a strong translation initiation context.
These findings are fully compatible with the in vivo translation analysis of TISU in a heterologous context supporting the notion that TISU is a strong translation initiator.
These results suggest that in addition to the −3 and +4 positions of TISU, sequences in the other positions contribute to its strong translation initiation activity (see also Fig. 5).
Given the strong translation initiation capacity of TISU, it is likely that in these genes it competes with the downstream AUG, and behaves as a strong inhibitor of translation.
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4) SLC35appearsars to be the only gene that showed strong enhanced translation in response to arsenite translation (i.e. preferential translation).
Dennis Kelly has provided a strong, abrasive translation.
The target gene was under the control of the high stringency phage T7 lac promoter [ 20] and a strong T7 translation initiation site.
Overall, the unit cell contains two nearly sixfold symmetric hexamers offset by a strong NCS translation of [1/3, 2/3, 1/2] (Patterson peak height 50% of origin).
Moreover, because Genome Canada has a strong knowledge translation mandate [ 30], many of these researchers had considered these issues before they were interviewed, and had well-developed, unorthodox perspectives that emerged in their responses.
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CEO of Professional Science Editing for Scientists @ prosciediting.com