Sentence examples for strong transforming from inspiring English sources
The resulting fusion oncoprotein, EWS/Fli-1, acts as an aberrant transcriptional activator with strong transforming capabilities.
Our results are also consistent with other studies that P2Y2 receptor has a strong transforming potential in vitro and in vivo (Hatanaka et al, 2007).
We and others demonstrated that large Maf proteins display strong transforming activity in chicken embryo fibroblasts, with MAFA being the most potent oncoprotein.
Expression of NPM-ALK converted BaF3 cells from IL-3 dependent to cytokine-independent growth, indicating a strong transforming activity of the kinase.
Our in vitro study also confirmed that NPM-ALK had strong transforming activity in lymphocytes and overexpression of NPM-ALK could induce the activation of the AKT/mTOR signaling pathway.
In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of highly invasive tumors when subcutaneously injected in nude mice.
Compared with the activated H-RASV12 oncogene, RAB1A displays stronger transforming activity as measured by cell growth, colony formation and xenograft tumor assays.
SUNE2 cells also showed much stronger transforming ability than 5-8F cells in colony formation assays and anchorage-independent growth assays in soft agar, and they only need 2 weeks to form tumors in nude mice.
Although the direct evidence of HPV-16 transcription and expression derived from integrated HPV DNA is still unclear, from previous studies, HPV E6- and E7-encoding cDNAs derived from integrated viral oncogene transcripts have a much stronger transforming capacity in primary cells than cDNAs derived from episome-derived transcripts [ 11].
However, Tpr-Met-IEC-6 cells were observed to display stronger transformed phenotypes than cells expressing the Grb2 or Shc-binding variants oncoproteins, for example in focus-formation and growth in soft agar.
The fast-falling snow and the strong winds transformed parts of the city into a municipal parking lot.
