As with tracing from the whole nerve strong terminal labelling was observed within the InM (Fig. 2e).
Initial analysis, performed without sequence masking or protein family filtering, reconfirmed the strong terminal bias in tripeptide composition seen by Gatto & Berg [ 18].
In what follows, we focus on networks where t= ℓ (note that this includes weakly reversible networks, i.e. networks where every linkage class is a strong terminal linkage class).
The construction of a cortical tibial osteoperiosteal flap to achieve a bony bridge during transtibial amputation, which represents a modification of the original technique described by Ertl, is a safe and effective procedure that creates a strong, painless, terminal weight-bearing stump.
To summarize, 5,524 cyt b with both N- and C-terminal regions (COB_NC), 749 cyt b with strong N-terminal but weak similarity at C-terminal region (COB_NC'), and 820 pairs of split form of cyt b (COB_N//C) were obtained from NCBI RefSeq database.
The cnidarian sea anemone Nematostella vectensis and hydra Hydra magnipapillata exhibit strong C-terminal amyloid potential but little potential for amyloid formation in their N-terminal βA4.
Consistent with cellular uptake of a short N-terminal leader PrP peptide [46], we found that mature (processed), full length PrPC contains a strong N-terminal transduction domain between residues 23 29 and a much weaker transduction domain at residues 100 110.
EWS is consisting of a strong N-terminal transcriptional activation domain (EWS-Activation-Domain (EAD), NTD, and amino acids (AAs) 1 264) and a C-terminal RNA-binding domain (RBD, CTD), extensively methylated at arginine residues and containing RNA-binding motif and a putative zinc-finger domain [ 3].
Additionally, the presence of a strong N-terminal mitochondrial targeting sequence (MTS) in AGT from X. laevis drives the mitochondrial localization of this enzyme, while the corresponding N-terminal MTS seems to be weak in human AGT [ 71].
As shown e.g. for LHCII and RbcS, which are post-translationally targeted to chloroplasts by strong N-terminal targeting signals in higher plants [ 40], protein targeting frequently takes place by localized cytoplasmic mRNA translation and demands for less strong chloroplast targeting signals [ 41].
AGO1 has a strong bias towards 5' terminal uridine, AGO2 prefers 5' terminal adenosine, and AGO4 prefers 5' terminal adenosine, guanine, or uridine [ 29].
