Even though the most strong Te-related Raman features, which are more commonly observed, are situated at lower frequencies (90 (E), 121 (A 1) and 142 cm-1 (E) [50]), these frequencies and width can be significantly affected because of the distortion of Te-Te bonds on the NC surface.
These results demonstrate that genes under stronger TE selection in human evolution, with respect to mouse, are also under stronger TE selection in recent human evolution.
First, we directly checked whether genes under selection show stronger TE selection.
Here for ocular surface, we aimed to produce a thin, transparent TE but where a stronger TE is required, for artificial skin perhaps, a thicker, stronger, less transparent TE may be more appropriate.
Interestingly, we found that genes that changed their TE during human evolution (either increase or decrease as compared with mouse) showed stronger TE selection than those with little change in TE.
TE may be more preserved in highly expressed genes as there are more mRNA copies that potentially consume more ribosomes and also more protein copies that may have translation errors, resulting in stronger TE selection.
Stronger negative TE selection was also observed in initial segments of highly expressed genes and in functional regions and positive TE selection in the same region for lowly expressed genes.
The strongest individual TE family correlation with PE is the negative correlation seen for L1 fraction versus PE (fig. 3 C ). L1 also has the largest negative partial correlation value with PE in the multiple regression analysis as well as the largest coefficient of determination (table 3).
In contrast, a strong reduction of TE diversity was observed in mammals (11 14 TE superfamilies) and the two bird species studied (7 9 superfamilies).
We need to make sure that it has really strong principles around Te Tiriti, and also around just transition.
