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In addition, evolution works on the sequence level, but proceeds under strong structural and functional constraints.
The degree distribution and hubs of healthy controls well described the properties of both resting state functional networks [5] and structural networks [6], reporting a high density of strong structural and functional core areas associated with DMN components.
This agrees well with the suggestion that functional proteins are usually under strong structural and functional constraints [ 71].
Indeed, there is a strong structural and functional interaction among plastid, mitochondrial, and nuclear genomes [ 11, 12].
GABAC receptors, which are constituted from ρ subunits, are a subclass of GABAA receptors, to which they have strong structural and functional similarities.
The latter corresponds to most of the tissue's dry weight, surrounding all chondrocytes and maintaining a strong structural and functional relationship with these cells [ 2, 3].
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This strong correlation between structural and functional assays validates this method to discover SERCA2a-PLB effectors for large-scale HTS campaigns.
To take up this great challenge of modern science and to solve the limited view of the brain provided just by one imaging modality, this article advocates the idea developed in my research group of a global approach involving new generation of models for brain connectivity mapping and strong interactions between structural and functional connectivities.
It is unclear what kind of evidence supports the statements in the description lines, the similarity of the hydrophobic pattern and the conservation of critical functional residues are stronger arguments for structural and functional similarity.
For example, Mueller et al. used sMRI-dMRI-fMRI approach and identified three brain areas with strong correlations between the structural and functional abnormalities: right temporoparietal junction and the left frontal lobe, bilateral superior temporal gyri, and the right temporoparietal region [90].
For example, even under strong positive selection, high structural and functional constraints can cause this index to be low, and in this sense, it gauges the level of adaptive constraint.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com