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TSG hypermethylation in cancer cells has strong specificity with respect to the tissue of origin and tumor-type-specific methylation patterns have been reported for primary human tumors and cancer cell lines [ 7- 11].
PCR-based methods are considered highly sensitive and also to demonstrate strong specificity via the design of primers that detect mRNA expression of tumor-specific genes such as cytokeratin (CK -20, uroplakin (UP) II, and epidermal growth faCK -20eceptor (EGFR) [ 13, 14].
The fabricated APOE4 electrochemical immunosensor exhibits strong specificity, high sensitivity, low detection limit and wide linear range.
These results demonstrate the strong specificity of DNA targeting through the CD44 receptor using HA of high molecular weight as a ligand.
In order to analyze glycan structures, we performed ELLA on the soluble SOM for the first time and found that it exhibits strong specificity to Datura stramonium lectin (DSL).
Among five mutant enzymes tested, two showed strong specificity to 1-OH, one showed moderate preference to 1-OH, one preferred 3-OH, and one showed broad specificity towards 1-, 3-, 4- and 6-OH.
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Both recycling methods showed strong specificities.
The high sequence similarity regions that we identified here and that are part of catalytic sites show strong specificities towards their corresponding GH families.
The scale exhibited moderate sensitivities (0.52 [mania] to 0.70 [ADHD]) and strong specificities (0.86 [mania] to 0.92 [GAD]) using the individual scales as the gold standards.
However, we identified a GC-rich region nested upstream of GazR1 containing successive CCs and GGs, theoretically offering stronger specificity.
The cleavable bond is located between P1 and P1', P1 being the strongest specificity determinant in the majority of the cases.
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