Exact(7)
These results are consistent with the reported strong signalling to the PI3-K pathway by the ErbB-2/-3 heterodimer yet indicate that signalling through both pathways is required for transformation [22].
These can be grouped into three main functional categories: 1) metabolic pathways such as Glycerophospholipid metabolism or Aminosugar metabolism, 2) pathways with a strong signalling component such as Parkinson's disease, Phosphatidylinositol signalling and Prostate cancer and 3) cell communication pathways such as Cell communication and Focal adhesion.
By contrast, ETR cells displayed an increase activation of Notch4 (N4ICD), suggesting a strong signalling through this receptor.
The six pathways (40%) unique to the CSCH group could be grouped into two main functional categories: (1) biosynthetic pathways, and (2) pathways with a strong signalling component such as ErbB- and Wnt signalling as well as tight junction.
As tumours showing evidence of strong signalling through a particular pathway are thought to have a high chance of responding to therapies directed against this pathway, the identification of reliable biomarkers could aid in selecting patients who are most likely to benefit from targeted therapy (Bild et al, 2006).
In early clinical studies conducted in patients with tumours characterised by particularly strong signalling through the VEGF2 receptor, for example, Kaposi's sarcoma and haemangioblastoma associated with von Hippel Lindau syndrome, SU5416 has demonstrated encouraging activity (Miles et al, 2000; Aiello et al, 2002; Jennens et al, 2004).
Similar(53)
"Decisions and a strong signal.
"This is sending a strong signal".
We should keep putting out strong signals".
"Sending the secretary of state is a very strong signal".
"This sends a very strong signal to drug traffickers".
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