The effects of SNO-cysteine and other nitrogen oxides on myosin are unlike those of alkylating agents (e.g. N-ethylmaleimide), which completely inhibit myosin cycling and lead to the formation of strong, rigor-like bonds with actin.
In spite of the above limitations, this study has strong methodological rigor through its design as a double-blinded placebo controlled RCT, compared to the earlier non-controlled studies of degenerative medial meniscus tears.
Empirical research on the role of specialists in the referral process is less well defined and mainly involves comparisons of primary care vis-à-vis specialist care without strong methodological rigor [ 19].
However, recent research in this context at first calls for professionalization by higher quality standards, including, stronger scientific rigor and theoretical foundation [13, 14].
For the second level (probable effectiveness), all criteria for Level I should be met, and additionally there should at least be preliminary evidence for effects of the intervention, based on exploratory studies, not necessarily of the strongest methodological rigor.
They can inform us, and even forecast for us, but they are only as strong as the rigor employed by their authors.
And Pilates, the discipline of controlled stretching and toning exercises beloved by dancers, keeps a large proportion of performers limber and strong for the rigors of the theater.
The Whitney show makes a strong case for the rigor and, often, the beauty of Koons's art, justifying the avidity of the collectors for whom his works are coveted trophies.
