Sentence examples for strong rationale of from inspiring English sources
A strong rationale of a metronomic chemotherapy based on the association between UFT and CTX derives directly from their synergistic antitumor activity in experimental mouse models of metastatic breast and hepatocellular carcinoma [ 19, 38].
In spite of the strong rationale for a role of genetic variants in Osterix influencing bone mass acquisition, we are not aware of any previous genetic studies in humans highlighting this association.
The potent antitumour properties demonstrated in this model of spontaneous bronchoalveolar carcinoma provide a strong rationale for additional evaluation of CCL19 regulation of tumour immunity and its use in immunotherapy for lung cancer.
Thus there is a strong rationale for development of IGF-1R targeted therapies, and IGF-1R inhibition might be expected to enhance the effect of cytotoxic chemotherapies or other molecular targeted therapies.
However, while controversial, this surprising epidemiological evidence provides a strong rationale for further investigation of the unique actions of PRs as mediators of breast cancer initiation and early progression (reviewed in [ 7]).
Further, elevated expression of both cav-1 and α1A-AR in advanced stage PCa epithelial cells provide a strong rationale for the understanding of the significance of α1A-AR signalling in androgen-independent PCa.
This work provides a strong rationale for clinical exploration of combination therapies of engineered oncolytic viruses with agents targeting immune checkpoints 58, 59.
Because tumour angiogenesis occurs in a very early stage of carcinogenesis, there is a strong rationale for earlier use of bevacizumab in the adjuvant setting [ 83].
Collectively, these findings have provided strong rationale for the development of small-molecule inhibitors of MEK1/2 for chemotherapeutic intervention in cancer.
Nevertheless, current findings provide strong rationale for further investigation of the potential use of IsoLG adducts as clinical biomarkers, both to identify persons at risk and to determine the efficacy of treatments targeting IsoLGs such as dicarbonyl scavengers.
These observations, along with the ubiquitous yet selective expression of BCMA on MMCs, provide a strong rationale for the development of mAbs targeting BCMA.
