But the president has weathered the troubles and grown stronger, purging adversaries from the military and firing 18,000 antigovernment oil managers at the state oil company, Petróleos de Venezuela.
Populations with slow inbreeding can be expected to possess less potential for heterosis because of stronger purging of recessive deleterious alleles (Wang et al. 1999; Whitlock et al. 2000; Theodorou and Couvet 2006).
And the greater the ambition, the higher the cost; the greater the purity, the stronger the purge.
The two stages are performed separately; the first is hydroxylation by a peroxy compound, particularly a peroxydisulfate or peroxymonosulfate, in aqueous solution with strong nitrogen purging; and the second is grafting of a vinyl monomer by the conventional ceric ion technique.
'I confess without shame,' wrote one working-class woman to the Women's Cooperative Guild in 1915, 'that when well-meaning friends said 'You cannot afford another baby - take this drug' I took their strong concoctions to purge me of the little life that might be mine.
The relative likelihood of motif gain and loss is still unknown, however, it is possible that if the effective population size becomes small for complex organisms, and interactions may appear ex nihilo in disordered regions at a high enough rate, natural selection might simply not be strong enough to purge them.
The loss of cladogenetic signal from older ERV-K lineages could therefore be a consequence of a strong host-driven purging that is more evident in the Homo and rhesus lineages.
By rapidly reducing heterozygosity, selfing exposed recessive mutations to atypically strong selection, likely purging many of the most deleterious alleles.
We predicted that strong selection usually purges genetic variation within populations; therefore, increasing the strength of stabilizing selection decreases the number of genetic and phenotypic variations.
This somewhat surprising result, which suggests a greater impact of constant low-level leakage than rare, large pulses of spillover, arises when strong selection rapidly purges maladapted individuals from highly variable spillover (Box 1; in line with the empirical observations of genetic recovery after an individual escape event in Crozier 2000).
