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However, when Rad52 is depleted by shRNAs in FANCM KO cells, a strong proliferation defect is observed, suggesting a synthetic lethality interaction between these two genes.
iTSCM cells showed strong proliferation upon TCR restimulation with resistance to cell cycle arrest and apoptosis, which suggested that iTSCM cells were more likely to be applicable to cancer immunotherapy8,24.
The current study demonstrated that MCs possessed strong proliferation ability but accompanied with rapid loss of chondrogenic ability during passage, indicating a poor feasibility to engineer the entire ear using expanded MCs.
Inoculation of the engineered bacteria into a microalgal culture in the absence of sources of C and N other than N2 and CO2 from the air, resulted in a strong proliferation of microalgae that was suppressed upon addition of the inducer.
Cytology of pancreatic juice showing large cell clusters with small nuclei and strong proliferation, indicating a suspected adenocarcinoma.
Mapping studies revealed that the peptide invariably induces strong proliferation of NZB CD4 T cells in vitro, and is the only sequence to stimulate responses by T cells from NZB mice prior to the onset of disease [8].
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Hidden beneath the strong proliferation-associated genes may be better clues to variable prognosis, e.g., proteins associated with the ability of cells to live in foreign sites, such as those represented in the PCT-TC signature.
The major distinction between the luminal A and B, both consisting of ER positive tumors, is the presence of a strong proliferations cluster in the luminal B subtype.
In this study, we found that epithelium-like MCF-7 could obtain stronger proliferation ability when they were co-cultured with AHFs and CAFs but not NFs.
Moreover, initial cell adhesion did not differ significantly between them, while the strongest proliferation was observed on the hydrogel with the highest degree of cross-linking.
In contrast to MCF-7 alone (MCF-7) or MCF-7 co-cultured with NFs (MCF-7/NFs), MCF-7 co-cultured with AHFs (MCF-7/AHFs) had stronger proliferation potential than that of MCF-7 and MCF-7/NFs, although it was weaker than that of MCF-7 co-cultured with CAFs (MCF-7/CAFs) tested by cell number (Fig. 2b) and cell cycle analysis (Fig. 2c).
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