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A strong negative interaction with IVCST may have masked a significant treatment benefit in LIPOS.
When Pol II GOF mutants and tfg2 alleles were combined, the most severe GOF mutant rpo21 / rpb1 G1097D exhibited a strong negative interaction with tfg2 ∆146-180 or tfg2 ∆261-273 (lethality and synthetic sickness, respectively).
ABC transporters from family c showed a strong negative interaction in the midgut and to a lesser extent in the fat body, implying that these cytoplasmic membrane transporters are important for infection control probably by transporting glutathione conjugates or lipid-derived eicosanoids that are known to be involved in insect response to infection [ 21].
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To the best of our knowledge, only one brain structure has been reported to contain neurons in which strong negative interactions have been observed as a result of noxious stimuli being applied simultaneously to two different areas of the body - namely the subnucleus reticularis dorsalis (SRD) in the caudal medulla.
Moreover, ccr4 mutations showed strong negative interactions with mutations in red1 and rrp6 (Fig. 6b).
For example, classical genetic interactions uncovered strong negative interactions with Rqh1 and Sgs1, which are orthologous DNA helicases of the RecQ family.
sua7 -1, sua7 -3, and sua7 -58A5 showed very strong negative interactions with all LOF Pol II mutants tested, with most double mutants being inviable.
Also the relative growth rate changes arising from negative interactions are generally higher than those from positive interactions, and these strong negative interactions are likely to be more dominant than positive interactions when assessing the similarity of neighbors.
As judged by colony size and density of double mutants compared with single mutants in serial dilution assays, we detected strong negative interactions with csn1, ddb1, and pnk1; moderate negative genetic interactions with csn5, rad26, rad17, srs2, swi3, and sde2; and only weak genetic interactions with raf1 and snt1.
Moreover, intra-sector centrality in a firm firm network has a stronger negative interaction with R&D than inter-sector centrality does in driving firm innovativeness.
The findings indicate that the structural properties of both firm GSI and firm firm networks have positive effects on innovativeness, but firm GSI network cohesion has a stronger negative interaction with R&D in influencing firm innovativeness.
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