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Furthermore, N. kaouthia venom expressed strong lethality (i.p. LD50: 0.79 μg/g) and myotoxicity (CK: 5939 U/l) in mice, and showed notable activity in PLA2 but weak activity in SVMP, l-amino acid oxidase or 5′ nucleotidase.
This is supported by the strong lethality observed on ubiquitous knockdown of itpr.
To rule out this possibility, we used DI-11 line to drive UAS-RNAi-HMGCR in the ca. When reared at 24°C, DI-11/UAS-RNAi-HMGCR larvae are smaller than control (half size) (Figure 5h) and a strong lethality is observed in third instars larvae, as very few adults survive: less than 1% and females only.
Almost all novel genes identified by GO term combinations of cluster 1 and 2 (GO terms related to proteasome function) showed a strong lethality in the iBeetle screen (≥70 % after pupal or larval injection; Fig. 3b, c).
We found that exposure to 0.3% oxygen induced consistent, strong lethality when compared with 1% oxygen exposure; therefore, we selected 0.3% oxygen for our severe hypoxia (sH) exposure experiments.
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Determining their UV sensitivity, we found that Xpd D234N (XP), G47R and G675R (XP/CS) showed the strongest lethality upon UV irradiation.
The miR-6/11 double mutant combination showed strong embryonic lethality.
However, ABT-737 displayed strong synergistic lethality when combined with Bortezomib.
In contrast, in combination with imp-β KetRE34, a decrease in Imp-α2 caused either by a deletion or by RNAi silencing resulted in strong embryonic lethality.
In budding yeast, strong synthetic lethality with oxidizing damage from ionizing radiation or Zeocin was identified in strains treated with a TORC2 inhibitor.
cdc-42 -directed RNAi confers strong embryonic lethality, and surviving animals are grossly defective in gonad organization as well as showing disruption of early somatic gonad polarity (Welchman et al. 2007).
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