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Five of the six remaining patients whose lesions were not detected by VBM presented with a strong lesion hyperintensity, and a significant part of their lesion was misclassified as white matter.
Furthermore, the extracts of bananas infected with A. terreus wild-type (and Δ akuB) caused strong lesion formation on fresh banana peels, which was hardly observed with extracts of bananas infected with the mutants.
Using this imaging method, nerve injury was reliably detected with strong lesion contrast even before the manifestation of symptomatic disease in asymptomatic carriers with confirmed disease-causing mutations of the TTR gene (Val30Met, Leu58His or Tyr69His).
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For strong lesions both scattering and displacement started during the pulse (Fig. 6(a)).
The slice displaying the strongest lesion was picked, bisected and transferred (separated by an injected and control hemisphere) to 2-ml tubes.
In the strongest lesion (Δ T > 67 K), increase of the scattering started only a few milliseconds after the start of the laser exposure [ Media 3].
From month 3 to 6, slight growth may be suspected in stronger lesions.
In the strongest lesions also a significant displacement of the retinal surface was visible (Fig. 5 (c)).
In the strongest lesions (400 W/cm, Δ T > 67 K, [ Media 8]) the whole image area and even the upper neural layer are affected.
Because of the unexpected sub-group occurrence, it was not possible to build strong brain lesion profiles with at least 5 to 6 mice for each sub-group (see supplemental data).
In the Eμ-myc model, a strong oncogenic lesion often leads to the B-cell transformation at an earlier developmental stage (Hemann et al., 2003).
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