Sentence examples for strong internalization from inspiring English sources

A combination of attributes such as the high IC50 value and strong internalization could be beneficial and further allude to the potential of 4-[18F]FEBZA an an effective melanoma targeting probe.

Tests C and D confirmed a strong internalization of the drug, at both concentrations (1.5 and 2 μg/ml, respectively,p < 0.05 calculate with respect to the control), that is much more enhanced by the complexation with the nanoparticles: in Test C the uptake increment of drug following incubation with Dox BTNPs was about 80% (p < 0.05), while in Test D it was about 40% (p < 0.05).

As shown in Figure 3C, the ubiquitination of K364 constitutively took place, but was not a strong internalization signal.

This data clearly indicates that upto 8  μM curcumin, there is strong binding and internalization of curcumin in the hydrophobic region of RNase L, but above 8  μM, there is a change in conformation probably due to binding of curcumin to different residues at some other sites.

Finally, if the amount of receptors is higher than the combined capacity of both pathways, CIE-internalization will be switched on equally strong as CDE-internalization for EGF-stimulations that are higher than this combined capacity (cf. Figure 2C).

However, some exception have been documented wherein multiple pathways including caveolae-mediated endocytosis were observed for internalization of strong cationic surface charged nanomaterials [105].

Moreover, GPCR dimerization has been shown to be needed for their proper expression, stronger ligand binding, phosphorylation, and internalization [21].

The absence of COOH-tail sequences may have resulted in a receptor that lacks sequences necessary for mediating rapid desensitization and internalization as well as strong plasma membrane expression (PME) [8].

Cy3-labeled PLL- g-PHis showed strong fluorescence in the nucleus after internalization, and high hemolytic activity upon pH changes was also observed from PLL- g-PHis.

The timing of GADR-1 protein accumulation was consistent with the microarray results and with our proposed role in gastrulation: GADR-1 immunoreactivity became strong near the time of endodermal internalization.

Close examination of the staining patterns of the tumor slides revealed distribution of the designed protein both inside and outside the cancer cells with substantial stronger staining inside the cancer cells, indicating internalization of the protein contrast agent.