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Although C16orf74 is a single molecular marker within this candidate progression-related gene classifier, it was sufficient to predict the risk of progression in NMIBC with a strong hazard ratio of more than 10 upon multivariate analysis.
This independent association remains strong (hazard ratio 2.9, 95% confidence interval 1.6 to 5.2; P<0.0005.2
DOI: http://dx.doi.org/10.7554/eLife.08825.009 Second, the subjects' decision processes reflected a strong, hazard- and evidence-strength-dependent trade-off between detecting changes and identifying steady signals, as predicted by the normative model.
These findings indicate that occupational heavy lifting is a particularly strong hazard for IHD among men who are not being generally physically active at work or in leisure time.
DOI: http://dx.doi.org/10.7554/eLife.08825.016 Second, as with the triangles task, this decision process reflected a strong hazard- and evidence-strength-dependent trade-off between detecting changes and identifying steady signals, as predicted by the normative model.
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When the interval was modelled continuously (assessing accumulation of risk by day), the effect was statistically stronger (hazard ratio 1.005 per day, 1.002 to 1.008, P=0.004).
Obviously, the discharge hazard rate without NB is the strongest hazard with its peak (about 25%) about 5 to 6 days after admission and a strong decrease afterwards; meaning the likelihood of discharge without NB decreases for each survived day in ICU.
The COX model achieved the strongest hazards ratios for the moderate and high mortality groups.
The strongest hazards for not quitting smoking were associated with renters compared with those living in homes owned outright (HR: 0.64; 95% CI: 0.52-0.78), labourers compared with managers (HR: 0.65; 95% CI: 0.46-0.92), and 12-month mental illness (HR: 0.77; 95% CI: 0.65-0.91) or lifetime mental illness (HR: 0.77; 95% CI: 0.64-0.92).
A strong association (hazard ratio (HR)=8.7/ P=0.001) was found between the loss of epithelial expression and RFS.
No demographic or clinical characteristics were significantly associated with relapse in bivariate analysis, even though a diagnosis with tuberculosis (Supplementary Table 1) showed a strong association (hazard ratio [HR]: 9.5; 95% confidence interval [CI],.9 97.9; P =.06).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com