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In HeLa cells expressing RFP-Rab5, EGFP-Rab7 and mCherry-LAMP1, which label early endosomes, late endosomes and lysosomes, respectively, HEC-23 treatment caused a strong enlargement of LAMP1-positive lysosomes, while no obvious change in Rab5- or Rab7-positive organelles was detected (Fig. 3A).
This mutation impairs MVB sorting and causes a strong enlargement of the late endosome which is then referred to as the class E compartment.
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For me it is clear that, without strong foundations, the Union will not come through a further substantial enlargement unscathed.
This chick analysis also reveals strong apical enlargement in cells on both sides of an artificial Hoxb4 border (Fig. 6K,L; supplementary material Fig. S6F-K).
Hence, strong apical enlargement is not a prerequisite for cell segregation and it may even be a consequence of nearby apical constriction.
Assume further that the trait is under such strong selection for enlargement that every QTL locus acquires the + substitution.
Among school-age children in Makueni District, Kenya, where chronic HSM is highly prevalent, chronic exposure to malaria infection has been shown to be associated with HSM, with a particularly strong association with enlargement of the spleen being observed (Mwatha et al. 2003; Wilson et al. 2007b).
DOI: http://dx.doi.org/10.7554/eLife.00961.015 There was also strong evidence for enlargement of BS cells as an early innovation in most C4 lineages, consistent with the suggestion that this was an ancestral state within C3 ancestors of C4 grass lineages and that this contributed to the high number of C4 origins within this family (Christin et al., 2013; Griffiths et al., 2013).
The elite's anxieties have transmitted themselves to the general public; opinion polls show stronger hostility to EU enlargement in France than in any of the other 14 member countries.Mr Delors himself sounds deeply ambivalent.
During the first part of the growing season climatic factors exert their strongest influence on radial enlargement of cells, whereas during the later part of the vegetation period, weather parameters mainly affect the cell wall thickening process (Rossi et al., 2006a,b).
If this is the case, one would expect to find a strong correlation between age-related enlargement of RFs and a reduction of PPS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com