Sentence examples for strong endpoints from inspiring English sources

The search for strategies to improve responsiveness to triptans, given that these anti-migraine drugs fail to achieve good results in many individuals when studies consider strong endpoints (e.g., 2 h pain or migraine freedom), identifies as a crucial issue treatment timing.

The amount of Gleason grade 4/5 in needle-biopsies seems to have prognostic value; however, it needs to be validated in large cohorts with strong endpoints.

There is a great need to design RCTs with strong endpoints, even though such designs may be difficult to implement for ethical and financial reasons.

But before these parameters may be validated as surrogates for strong endpoints of major cardiovascular events, better definition of their accuracy is needed.

Strong endpoints, such as REILD, had a low incidence, while weaker endpoints, such as grade 3/4 toxicity, were heavily confounded by pretreatment morbidity, tumour cell type, and disease progression.

However, there are some concerns with the results presented by Sánchez-Sánchez and colleagues [ 1] and doubts about the achievement of what they presented as 'dry resuscitation', especially when strong endpoints such as intra-abdominal pressure and Sepsis-related Organ Failure Assessment (SOFA) are considered.

Aspiring medical wearable entrepreneurs should start by figuring out the strongest endpoints for the disease they want to impact.

We tested several values for these parameters and finally selected λ 3=0.33 (nT/year 3)−2 (the same as used in CHAOS-4l) and λ 2=100 (nT/year 2)−2 (a stronger endpoint constraint than used in CHAOS-4l).