For example, if the kinase was constrained to a subset of proteins by strong docking interactions, the potential to phosphorylate other proteins might be limited.
Indeed we observed a strong docking defect in synaptotagmin- 1 null cells, similar to Snap- 25 null cells (de Wit et al. 2009).
Indeed, Snap- 25 deficient cells exhibited a strong docking phenotype, which was, however, slightly less severe than in Munc18-1 or syntaxin-1 deficient cells (de Wit et al. 2006; Voets et al. 2001) (Fig. 1).
On one hand, both Nfs1 and Yfh1 show stronger docking scores with the four scaffold proteins.
In other words, the stable pairing of G C provides stronger docking power than does A T pairing, thus encouraging mismatches at the focal nucleotide during DNA replication by obscuring polymerase editing function.
Orion can build a hurricane-proof concrete pier and a dock strong enough to hoist a 300-foot-long ship.
The strong presence of dock workers and trade unions earned it the nickname 'Red Haifa.' In addition, many prominent Arabs in the Israeli Communist Party, among them Tawfik Toubi, Emile Habibi, Zahi Karkabi, Bulus Farah and Emile Toma, were from Haifa.
A comparison of the predicted docking energies from both programs is shown in Figure 1B, demonstrating a strong correlation between the docking results.
Duluth was a Democratic bastion — the unions were strong on the Lake Superior docks — and Nides's parents instilled in their children the importance of public service.
It advised passengers to travel outside peak hours if possible on Thursday, and walk or cycle – ideally on their own bike, with the cycle hire scheme expected to be in strong demand, despite extra docking stations being added in central London.
