Sentence examples for strong deleterious effects from inspiring English sources

This would explain the absence of strong deleterious effects in the face of strong ta-TRIM expression.

Sequence variation in human NAD metabolic enzymes reveals that most amino acid changing SNPs are at very low frequencies suggesting strong deleterious effects of most of them.

Because large-scale perturbations in expression levels arising from changes in gene dose might have strong deleterious effects, the evolutionary response should be strong.

High frequency SNPs are likely to be polymorphisms which are either selectively neutral, under balancing selection or currently undergoing positive selection, but unlikely to have strong deleterious effects.

Surprisingly, we found that nonsynonymous mutations in highly conserved core genes can have strong deleterious effects on fitness, and yet we found no evidence that these mutations were removed by natural selection.

In such genes, as surmised by Wilson et al. (1977), even subtle amino acid mutations would tend to lead to sufficiently strong deleterious effects to be noticed by natural selection.

Classic examples are some ascomycetes in grasses which might have gone unnoticed if they did not produce alkaloids having a strong deleterious effect on cattle feeding on the respective grasses [13].

Predictive software tools such as SIFT, PolyPhen-2 and Mutation Taster, suggested a strong deleterious effect on the protein.

Interestingly, there was also an unexpected strong deleterious effect of the low-plated allele during early stages of development.

The absence of obvious hot or cold spots (regions) of NUPT origin suggests that no chloroplast genome regions have a strong deleterious effect on the host genome when transferred to the nuclear genome.

RPA4's coefficients imply that it has a strong deleterious effect in cluster 3 (exacerbating the jump in hazard), while it has a strong protective effect in cluster 5. Contrast this change with RPA3, which only increases risk in cluster 5, and TOP3A, which is protective in cluster 3 only.