Sentence examples for strong deleterious effect from inspiring English sources
Classic examples are some ascomycetes in grasses which might have gone unnoticed if they did not produce alkaloids having a strong deleterious effect on cattle feeding on the respective grasses [13].
Predictive software tools such as SIFT, PolyPhen-2 and Mutation Taster, suggested a strong deleterious effect on the protein.
Interestingly, there was also an unexpected strong deleterious effect of the low-plated allele during early stages of development.
The absence of obvious hot or cold spots (regions) of NUPT origin suggests that no chloroplast genome regions have a strong deleterious effect on the host genome when transferred to the nuclear genome.
While small developmental delays are expected to have a strong, deleterious effect on fitness in an organism with a short life cycle and a boom bust lifestyle such as C. elegans, they are likely to have a smaller impact on organisms with a longer life cycle.
We also found that reducing sequencing depth would have caused us to miss the significantly associated site in YPW89 the mutant with the largest effect on mean fluorescence of the P TDH3 -YFP reporter gene because of its strong deleterious effect on fitness (see Figure S10, C and D).
This would explain the absence of strong deleterious effects in the face of strong ta-TRIM expression.
Because large-scale perturbations in expression levels arising from changes in gene dose might have strong deleterious effects, the evolutionary response should be strong.
Sequence variation in human NAD metabolic enzymes reveals that most amino acid changing SNPs are at very low frequencies suggesting strong deleterious effects of most of them.
High frequency SNPs are likely to be polymorphisms which are either selectively neutral, under balancing selection or currently undergoing positive selection, but unlikely to have strong deleterious effects.
It should also be noted that the mutation rate v refers only to those mutations that enjoy selective advantage because of the pleiotropic effect within populations but generate strong deleterious effects when they are brought together in hybrid individuals.
