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Prevailing wisdom suggests that when strong associations are measured in observational studies, they are unlikely to be fully attributed to confounding, as strong confounders are likely to be recognized, measured and controlled for in the analysis.
We believe it unlikely that such strong confounders exist, nonetheless the possibility remains that unmeasured confounding variables may explain our findings.
These relationships persisted after adjustment for strong confounders.
These criteria enabled adjustment for strong confounders and ensured time comparability for exposure.
In the present study, country of origin and parity were strong confounders.
We identified two effect modifiers (age and sex) and two strong confounders (travel time to hospital and mortality).
Similar(40)
We conducted a bias analysis to examine the potential impact of uncontrolled confounding due to smoking, a potentially strong confounder, on our observed associations between PTSD and CVD events.
Although we cannot rule out the possibility of bias due to residual confounding, our sensitivity analyses suggest that even a strong confounder (one associated with a 5-fold increase or decrease in prostate cancer risk) will not fully explain the observed differences between aspirin and propionate use.
The effect of time is another strong confounder not addressed by the majority of studies included in this systematic review.
In all but one study [28], DI (a known strong confounder) was either not reported or not considered in the analyses.
We show that area of residence is a strong confounder for infant IL-10 and TNF-α response to LPS.
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