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It is important to simultaneously induce strong cell death and antitumor immunity in cancer patients for successful cancer treatment.
Collectively, these results indicate that ectopic expression of APP induces strong cell death in the Drosophila nervous system.
However, because Caf1p55 depletion itself induces a strong cell death phenotype in both control and rbf1 mutant eyes, we could not make a strong conclusion from this result.
Finally, concurrent induction of both strong cell death and increased anti-tumor immunity by combination therapy may provide strong antitumor effects in living organisms.
Our data proved the anticancer effects of 2DG in prostate cancer cells by inhibiting cell proliferation, but did not show strong cell death (Fig. 1).
We also noticed that expression of HepCA triggers strong cell death (data not shown) that resulted in a dramatic reduction of the posterior compartment.
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Further supporting such a hypothesis is the finding that simultaneous treatment of A. thaliana suspension cells with two different harpins, HrpNEa and HrpWEa, induced a stronger cell death than the cell death observed in response to each harpin supplied separately [61].
Since our foregoing data with mi-grim expression showed the strongest cell death defect, we attempted to gain supporting evidence for the grim's proapoptotic roles.
Indeed, Egr induced stronger cell death (AO staining) and Bsk activation (puc-LacZ expression) than Hep in the wing disc (Supplementary Figures S3b, e, i and S4).
These results were not explained by the difference between expression of EVER2 fragments, as shown by d4 fragment that induced the strongest cell death despite lower expression.
Interestingly, we observed strong HR cell death in npr1 plants but also in atg2 nplantsants.
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