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Despite the lack of a strong mouse disease model, enzyme replacement of recombinant human GALNS for Morquio A was able to proceed into clinical development, and recent clinical investigation has largely been focused on the evaluation of enzyme replacement therapy in Morquio A (Clinicaltrials.gov;[Hendriksz et al., 2013b].
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This suggests that differences in the mouse and human PDX1 cistrome contribute to the differential expression of genes between mouse and human beta cells, as is illustrated by the Sytl4 gene, which is uniquely expressed in mouse beta cells and is associated with a strong mouse-specific PDX1 ChIP-Seq peak that overlies a consensus Pdx1 binding motif in the mouse that is absent from human.
The qPCR confirmed strong and mouse ESC-selective expression for both miR-302 and uc.283-plus (Wilcoxon test P-value <0.01) (Additional file 6).
Sim1 expression was considerably stronger in mouse ventral midbrain, compared to hindbrain.
However, the drop in rates implies that negative selection near TSSs is stronger for mouse genes than in the rest of mammalian species.
Gata4 is in the heart-red module (c = 0.00), which has a strong within-mouse correlation to the heart-green module (r w = 0.89) [Additional files 2, 13: Supplemental Figure S9].
Genomic properties such as gene density or GC content are obvious candidates but concerning these features neither the two repositioned HeLa loci nor the two strongest repositioned mouse loci stand apart from other investigated loci (Tables 1 and 2).
The bioluminescence was stronger in mice that received HSVova, compared to control mice that were given HSVlac in which the bioluminescence was below the threshold of detection (Figure 1A, upper right panel).
The effects of caffeine were strongest in mice displaying mild cognitive impairment.
Overall, the inflammation-induced upregulation of BDNF is stronger in mice compared to rats.
This inbreeding depression typically begins to diminish by generation 8. Therefore, inbreeding depression is stronger in mice than in medaka.
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