Sentence examples for stromal matrix from inspiring English sources
We hypothesize that cooperative interclass SLRP interactions are involved in the regulation of stromal matrix assembly.
Doxycycline (DOX) has been proven in vitro to inhibit MMP-mediated degradation of stromal matrix.
This article describes paradoxical activation of melanoma-associated fibroblasts by a BRAF inhibitor, which leads to increased stromal matrix stiffening and elevated β1 integrin SRC FAK signalling and drug resistance in melanoma cells.
However, because of the highly organized nature of the stromal matrix, the attempts to reproduce corneal stroma might follow a scar model.
Degeneration of the stromal matrix with spheroid formation in lymphoid organ was observed among the Vp infected natural and experimental animals.
Morphological and histological analyses highlighted that the presence of fibroblasts resulted in the deposition of a stromal matrix rich in collagen leading to the formation of tumor microtissues composed of a heterotypic cell population embedded in their own ECM.
Matrix metalloprotease (MMP) activity is important to enable cells to overcome the barrier constraints imposed by basement membranes and stromal matrices in vivo.
As both basement membrane and stromal matrices present a steric barrier to cell transmigration, matrix remodelling is a necessary and critical contributor to metastasis.
On the other hand, in late stage stromal matrices (tumor-associated), this combinatorial approach inhibits velocities to the same extent as beta1-integrin blockage alone.
Therefore, our observations imply that "staging" stromal matrices, analogously to clinically relevant "tumor staging," might be an important step in assertively selecting invasive drug inhibitors.
Collectively, our experiments show that matrices reconstituted from Matrigel do not adequately reflect the barrier function of basement membranes, in either transwell or 3D invasion systems, whereas the barrier function of stromal matrices can be mimicked using polymerised collagen I.
