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The failure of vancomycin to increase synthesis of the stringent factor ppGpp while modulating expression of many stringently controlled genes suggests the former, but simultaneous induction of transcription of σB and the σB regulon, and of σE and the σE-dependent gene SCO3202, by all three antibiotics would be indicative of the latter.
Some analysts said Aetna's troubles portended the demise of stringently controlled health maintenance organizations of the type that Mr. Huber bought from U.S. Healthcare in 1996 to begin Aetna's transformation.
Owing to its cytotoxicity, bacterial intracellular levels of cysteine are stringently controlled via several modes of regulation, including cysteine degradation by cysteine desulfhydrases and cysteine desulfidases.
The Engineering Development Unit (EDU) is a tightly closed, stringently controlled, ground-based testbed which provides a broad range of environmental conditions under which a variety of CELSS higher plant crops can be grown.
Such interactions must be stringently controlled for cell-based tissue engineering and regenerative medicine therapies, and methods for studying and controlling cell cell interactions are being developed using both biomedical and engineering approaches.
Using these peptides as models, it may be possible to design similar low affinity peptide inhibitors of protein drugs which will increase their stability and/or allow for storage under less stringently controlled conditions.
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We show that the new method stringently controls the false discovery rate and asymptotically selects the correct biological model.
Luckily for the museum's mummies, more stringently controlling the humidity inside the collection is a relatively easy fix.
Running on a simple algorithm, the system stringently controls the thickness of each of the multilayers thereby avoiding thickness error build up throughout the deposition process.
This further highlights the importance of stringently controlling relative protein levels when investigating the activity of different TDP-43 isoforms.
Therefore, by controlling the levels of PtdIns(4,5 P2 and PtdIns 3,4,5 P3, PI3K and PTEN thus stringently control the signaling from phosphoinositides defining epithelial plasma membrane identity and epithelial polarity.
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