It is in these primary developmental processes that the most stringent selection against the presence of deletions takes place; the survival of M2 plants having past the seedling stage was hardly compromised although many phenotypic aberrations were observed.
When the less stringent definition of survival commonly used by embryologists was applied, i.e. embryos with ≥50% of cells intact, survival remained elevated in the intervention group [OR (95% CI) 2.4 (1.3, 4.2); P = 0.003].
Recovery of live attenuated S. Typhi vaccine strains can be difficult because the mutations necessary for safety in humans often compromise survival in stringent selective enrichment media.
Doses as low as 106 vp of Ad (4×107 vp/kg) reduced weight loss and increased survival against stringent lethal challenge.
Importantly, cells growing in high glucose quickly lost any metabolic synchronization and grew unrestrictedly, abandoning the stringent "quality control" and "survival" processes which the genes that peak in the RC phase typically enable.
To further explore the inhibitory ability of SAHA on PaTu8988 cell proliferation under more stringent conditions, the colonial survival assay was performed.
We show that the SapM mutant (but not the ManLAM mutants) is a better vaccine than the parental M. bovis BCG strain, even when assessed in the most stringent tests (long-term survival of TB-challenged animals).
Despite the limitations of the study design, however, we found no convincing evidence for a therapeutic effect of thymostimulin used as a single agent, in particular with regards to the most stringent study endpoint overall survival.
Rel proteins in bacteria synthesize the signal molecules (p ppGpp that trigger the Stringent Response, responsible for bacterial survival.
An even lower dose of 106 vp demonstrated reduced weight loss and increased survival against this stringent lethal challenge.
