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Even though this number is an underestimation, due to the stringent strategy for calling somatic mutations that allowed a false negative rate of 0.41 (Supplementary Table 3), it was useful to define 2 subsets of old SCCs.
If we impose a more stringent strategy (i.e. P < 0.05 in both conditions except for tPAV genes which are expressed in only one condition), only 351 genes are shortlisted (data not shown).
Therefore, a stringent strategy was adopted to construct two cohorts of contrasting phenotypes, i.e., the large and small stature cohorts.
The stringent DDI-based prediction approach reported in this work provides a stringent strategy for predicting host-pathogen PPIs.
As the aim of this study was to understand the molecular mechanisms underlying adaptation to long-term exposure to heat stress in Pecten maximus, a very stringent strategy was adopted to identify the consistently differentially expressed transcripts.
It is important to note that this discovery was made possible by the stringent strategy we employ which avoids assigning an organism to a lower-level taxonomic group if the evidence does not support this assignment, a feature not available in other taxonomic profiling tools.
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"We also need to devise more stringent strategies to prevent them going back to alcohol once the transplant has been performed". · Between 1996 and 2000, alcohol-related liver disease necessitated almost 500 liver transplants at an estimated cost of £23.5m.
DNAm of B cells, CD4 and CD8 T cells, granulocytes, monocytes, and natural kills (NK) cells sorted using the stringent FACS strategy were compared to stringently sorted nRBCs.
Since the stringent FACS strategy was designed based on results from the standard FACS strategy, sample collection and 450K array runs for cells collected by these two protocols were done separately.
A stringent selection strategy resulted in the identification of 60 unique HIV-1 peptide phage, which were subjected to sequence analysis and mapped onto the ITM1 envelope sequences.
With Heinz's stringent streamlining strategy moving forward which has already resulted in the closing or exiting of 21 factories and businesses it shouldn't be a surprise to see a couple of minor fine-tuning adjustments to follow the massive dumping it made yesterday.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com