Sentence examples for stringent selectivity from inspiring English sources
When considering a more stringent selectivity cut-off value, namely 3 pIC50 units, we obtained a set of 61 compounds.
Current multistep models of this excision repair pathway accommodate its broad substrate repertoire but fail to explain the stringent selectivity toward damaged nucleotides among excess native DNA.
These results indicate that S5a has more stringent selectivity of ubiquitinated target proteins than does HR23B.
In general however these compounds are not endowed with stringent selectivity.
Despite stringent selectivity of GULT1 transporters, there are studies suggesting possible GULT1 mediated uptake of glucose prodrugs.
In contrast, SETDB2, a putative PKMT highly homologous to SETDB1, did not transfer the alkyne moiety from 1; this suggests that 1 might provide stringent selectivity among PKMTs.
17, 18 To select this novel SERM, a stringent selection process was implemented to assess its biological activity and tissue selectivity on key endpoints, which included the uterus, lipid metabolism, bone remodeling, and central nervous system function.
This group of enzymes has undergone functional evolution from a shared ancient evolutionary origin to generate a selection of subfamilies with stringent substrate selectivity's [ 14].
The stringent binding selectivity of EGS is further emphasized by the observation that only the 7- S ,8- S) stereoisomer of EMDF complexed with EGS; the 7- S ,8- S) istereoisomernt at lof lEMDFs in the EMDF preparation) was excomplexedue to poorer steric complementarity with thEGSGS acthee site.
The lack of utilization of host-derived or supplemented fatty acids may be due to the more stringent substrate selectivity of these nrPKSs or, in the case of the fed substrates, excessive catabolism or a failure in uptake/compartmentalization by the yeast host.
The glycoform preference discovered in this work is in line with this finding and suggests a more stringent substrate and glycoform selectivity of EndoS compared with EndoS2.
