Sentence examples for stringent seed from inspiring English sources

CONCLUSIONS/SIGNIFICANCE: In conclusion, our results indicate significant promise for energy-based miRNA target prediction that includes a broader range of targets without having to use conservation or impose stringent seed match rules.

Comparisons with TargetScan and EIMMo require stringent seed pairing, while miRBase requires moderately stringent seed pairing.

Because some miRNAs have less stringent seed region pairing and instead exhibit homology to target transcripts over their lengths [41], [71], we also compiled a list of related miRNAs using the criteria of full-span homology.

TargetScan predicts miRNA targets based upon stringent seed pairing as well as site number, type, context, and conservation (Bartel 2009).

Other miRNA genes might exist that regulate similar target sets like mir-34 but have been missed by our stringent seed classification method.

DIANA-microT 3.0 [83] searches in the UTRs for stringent seed paring (at least 7 consecutive Watson Crick pairs) to the miRNA.

Also in order to control false positive rate of prediction, we concentrated on the methods that use stringent seed-matching criteria and consider the evolutionary conservation of binding sites [34].

If we use a more stringent seeds setting, the resulting clustering will be smaller and the N50 will be shorter; and otherwise there will be lots of singleton clusters (only one read in it) that would be discarded.

Furthermore, mass selection has been increasingly tainted by illegitimacy indictments through stringent formal seed market regulations, aimed at ensuring seed quality, consumer protection and high productivity rates.

There were two miRNA strategies in C. sinensis for its parasitic life: keeping a large category of miRNA families of different animals and keeping stringent conserved seed regions with high active innovation in other places of miRNAs mainly in the middle and the end, which were perfect for the parasite to perform its complex life style and for host changes.

For other more stringent definitions of seed matches (7mer: complementarity at nt 2 8 or complementarity at nt 2 7 plus an A at target position 1; 8mer: complementarity at nt 2 8 and an A at target position 1) the percentage of the miR-1 and miR-124 targets with seed matches was lower but still highly significant (Table 1).