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The number of requirements (some of which are very stringent) results in a very low probability that they will all be met.
When European banks have introduced new value-at-risk models to comply with additional Basel requirements, they have produced more stringent results.
Stabler's data were based on PCR product arrays which although provided higher signals as full CDS were printed, but were prone to cross-hybridization. Microarrays used by our group were 70mer-based spotted array that produced more stringent results.
More stringent results have derived from longitudinal studies.
First, in the two GC (or AU -insensitive quAU -insensitiveme of the codons or amino acids are actually sensitive to purine variation, both symmetry and uniformity are at work, and the narrower distributions appear to give more stringent results.
More stringent preclustering is not expected to yield more stringent results: The error rate of our specific amplicon pyrosequencing run was 0.6%, which is lower than the amount of variation we removed by preclustering.
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"They end up with such a less stringent result that cannot be defended," he said.
A similar, but less stringent, result is found for further crystallization in the spinline.
Current FDR adjustment strategies are dependent on the magnitude of differentially expressed genes, gene expression variability, and sample size [34], and they are often too stringent, resulting in a large number of false negatives.
Controlling for FDR can be too stringent, resulting in a large number of false negatives [ 21- 23].
Our criteria for significant expression were stringent (resulting in the elimination of 32,353 probes for which nevertheless at least one array detected significant expression).
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CEO of Professional Science Editing for Scientists @ prosciediting.com