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Secondly, to bring these data in line with more stringent recent FDA-recommended definitions, a responder was also defined as a patient with an improvement of at least 2 points compared with baseline; this definition excluded any patient with a baseline score of 0 or 1 on the 5-point Merz scale, as they could not achieve a 2-point improvement and therefore could never qualify as a responder.
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Immigration restrictions have become so stringent in recent years that the illegal immigrants among these customers were too afraid to travel home to Ireland for the holidays.
The enforcement of censorship regulations has become more stringent in recent years.For now, at least for makers of short-form films, the internet can compensate.
Concrete temperature criteria, such as the maximum temperature limit and the maximum temperature difference limit between the interior and exterior of concrete, have become more stringent in recent construction projects.
The issue of proper patient selection for retreatment after TACE has become more stringent in recent years due to the availability of alternative treatments such as sorafenib [ 33], and radioembolization [ 24].
The definition of bluegrass here is not stringent — on a recent Sunday the singer and songwriter Kelli Rae Powell led an Americana trio consisting of ukulele, upright bass and harmonica — but the mood is convivial (it's not unusual for toddlers to populate the dance floor), and the drinks are always strong.
The recent stringent criteria of p-values and replications set for genome-wide association studies represent a major effort to establish credibility in genetic association studies.
Connecticut, New York and New Jersey have enacted more stringent lending laws in recent years, after booming home sales brought sharp increases in mortgage complaints.
Often, the steepest rent increases are found in places, like San Francisco, that have stringent building regulations: a recent study of the city found that fewer poor residents had been displaced in neighborhoods with more new construction.
Our criteria for paralogs, as for the previous works, are stringent and detect relatively recent paralogs.
Therefore we thought the threshold (r2 = 0.4) in our study might be adequately stringent according to a recent study [ 17].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com