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While most identified genes show a strict monoallelic expression in all cDNA samples tested (from 8 to 11 independent samples), two genes have a less stringent profile.
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Some have speculated that all of the "low-hanging therapeutic fruit" has been harvested, and others have opined that the increasingly competitive market and regulatory environment is demanding more stringent benefit/risk profiles for new therapies.
One may either carry out an alignment of part of the EST- or protein sequence against the entire profile (stringent), or a local alignment of the sequence against part of the profile (relaxed).
Marker discovery based on differential gene expression profiling, stringent sensitivity and specificity assays, and well-annotated patient samples can rapidly prioritise and identify novel MRD markers of NB (Cheung et al, 2008).
By Karen Swenson The New Yorker, November 9, 1968 P. 217 The shadow of her profile lay stringent View Article By Kathryn Schulz By Adam Davidson By Junot Díaz By Robin Wright.
These cut-offs are more stringent than previous ribosomal profiling experiments and standard RNAseq practice, and their combination should provide robust identification of transcripts that undergo active translation.
We used a stringent approach in methylation profiling by filtering out CpG probes that overlapped repeats or known SNPs, which might have produced unreliable results.
We hypothesized that stringent analysis of expression profiles as well as regulatory networks of the neoplastic cell would provide novel information that facilitates further delineation of the genomic basis of small intestinal neuroendocrine tumors.
An unsupervised hierarchical clustering analysis can then divide patients into groups based on their B-cell profiles, and stringent correlations of B-cell fingerprints with clinical, immunological and other emergent features can be identified.
By whole-genome expression profiling and stringent significance tests we identify genes and gene groups de-regulated in the motor cortex of patients with sporadic ALS, and interpret the role of individual candidate genes in a framework of differentially expressed pathways.
Placing the SVT in such close proximity to the beam puts stringent requirements on the beam profile and beam position stability.
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