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As explained in the previous section, due to how interactions are scored, direct and module-based methods will infer different kinds of networks at stringent precision thresholds.
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At a more stringent, precision-optimized setting, the DT classifier identified only 10% false positives, maintaining ∼60% of true positives.
Increasingly stringent process repeatability and precision of assembly requirements are common for high-volume manufacturing for electronic, automotive and especially medical device industries, in which components for disposable medication delivery devices are produced in hundreds of millions annually.
Hence, in order to maintain high precision, a stringent domain Tanimoto similarity cut-off of 1 (i.e. requiring a 100% overlap in domain presence and absence between two proteins) was chosen and the top n predicted non-plasmodial targets considered was set to 4 for further analysis.
As the sequencing-derived DMR definition becomes more stringent, Probe Lasso's precision begins to drop away more quickly than the other methods.
For example, the stringent thresholds generated using the precision metric can be applied in cases such as candidate safety profiling, when outputs require few false negatives and accurate identification of dangerous compounds.
Our strategy is to introduce more stringent requirement to increase the precision of the reported best hits.
Next, we investigated whether the results obtained with the tested candidate promoters in primary breast cancer cells could be reproduced in the most stringent available preclinical model of precision cut breast cancer tissue slices.
As precision requirement becomes more stringent, it is not sufficient to consider only size tolerance of circular and cylindrical parts.
These very stringent requirements are dictated by the precision measurements aimed at this collider to complement the exploratory experiments at the Large Hadron Collider.
The most stringent tests of quantum theory are precision tests of quantum electrodynamics (QED); these have now been verified to an accuracy of 10−12 using a one-electron quantum cyclotron [6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com