But while the commission argues that a stringent point system will put drivers on notice to drive more carefully, taxi owners and their allies say that six points can be amassed in just one or two traffic stops.
Quantitative RT-PCR data for AAEL004188, AAEL004188 and he act5C gene used as a control by Hotopp et al. [ 5] matched the array results, as shown in figure 3. The act5C gene is, as the authors note, highly and constitutively expressed and may in fact be an overly stringent point of comparison to assess whether horizontally transferred genes are likely to be functional.
While the latest FDA guidelines from March 2015 [30] include more stringent points on quality, it is not known or clear if any of the additional suggestions made will be implemented, checked, and complied with in the future.
As the criterion for a positive test becomes more stringent, the point on the curve corresponding to Sp and Se (point c, Figure 3a; point d, Figure 3b) moves down and to the left (lower Se, higher Sp); if less evidence is required for a positive test, the point on the curve corresponding to Sp and Se (point a, Figure 3a and 3b) moves up and to the right (lower Sp, higher Se).
MACE is considered a more stringent end point with arguably less ambiguity and bias and more certain ascertainment than some "softer" end points.
When we used a more stringent cut point of P<0.01 instead of P<0.05 to define genes that were increased in EGFR-transfected MCF-7 cells (576 genes in all), 28 overlapped with the mutant EGFR NSCLC signature (chance expected of seven genes, P<1E 10, one-sided Fisher's exact test).
Taking into account that phages are capable of extravasation within an hour and that tumor vasculature is more porous than normal tissue, a stringent time point of 10 minutes was used for in vivo circulation within the CPC Apc mouse model to isolate phages that first bind to the target tissue.
Considering the cost implications of providing one to one CCBT sessions, a more stringent cut point for high risk may be more useful.
The findings were replicated in sensitivity analysis using an alternative, less stringent cut point of >18 to define high FRS (Supplementary Table 2).
Third, beneficial associations of MVPA with metabolic risk factors might have been missed as a result of the definition of MVPA, as suggested by the stronger, albeit non-significant, inverse associations with waist circumference, systolic blood pressure and clustered metabolic risk when we used a more stringent cut point of ≥4.0 METs, as opposed to ≥3.0 METs.
The majority has interpreted certain provisions of an offense so broadly as to render superfluous the more stringent, on-point requirements of a narrower provision of the same offense.
