On the other hand, however, the more stringent epigenetic phenomena, and those that are triggering more widespread fascination, are those that typically resist change, those states that defy in their stability the inherent disruption of genome regulation associated to the cycles of reproduction in cells or organisms.
16 Several justifications have been suggested for so called research exceptionalism the phenomenon whereby more stringent rules are applied to research than to usual clinical practice, even for treatments in widespread use.
We cannot rule out the possibility that the criteria for the elimination of sequences containing CpG islands might not be stringent enough, or that other phenomena, linked to transcription or to translation, could induce the observed variations in GC3 content.
He didn't want to use a very stringent design process, he wanted the unexpected phenomenon to occur – and use that".
The phenomenon is phenotypically similar to the stringent response which is induced by ppGpp synthesized when cells encounter amino acid or carbon starvation [10].
To select a conservative set of candidate loci based on this phenomenon, we chose to impose a stringent intersection rule, requiring a threshold of the top 1% of the delta-Rg distribution in both cohorts, in addition to evidence of a strong cis- acting eQTL (genotype effect p < 5 × 10-8) in both cohorts.
Arguably the most stringent study conducted to date to elucidate whether the phenomenon of cell fusion occurs under true physiological conditions was carried out by Nern and colleagues in 2009 [ 31].
This specificity also makes more stringent demands on any model that proposes to account for the phenomena.
Moreover, ethical aims for contrasting energy poverty, heat-related diseases and deaths, availability of food and water, infections and viral-bacteriological risks, meteorological extreme phenomena, such as floods and intense and destructive precipitations, are stringent and pressing targets.
For example, few experiments in paranormal phenomena, such as clairvoyance, which have given positive results under apparently stringent conditions, have made converts among scientists.
