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Especially for various mutants, we expect that even if knock up/down or mutant genes can influence normal gene expression profiles, the proteins affected by them may still involve in similar stringent pathways and hold similar co-expression trends or patterns.
Pluripotency and cell survival pathways were the most stringent pathways that emerged from the genes upregulated in both groups.
For example, in L. pneumophila, a close relative of C. burnetii, the stringent pathways are important factors in modulating the virulent attributes that help its survival in the host [ 77].
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She was a vocal critic when Congress failed to pass legislation last year revamping immigration law and has also backed proposals favored by some immigrant advocacy groups, including a temporary worker program and "a strict and stringent pathway to citizenship" for illegal immigrants already here that would include learning English and paying fines.
We develop a theoretical model to study the dynamics of the stringent response pathway.
The stringent response pathway is initiated in the subpopulation with high rel activity.
The stringent response pathway involving MprA and MprB is initiated when the mycobacterial population is subjected to stresses like nutrient depletion.
The mathematical model developed by us to study the dynamics of the stringent response pathway predicted bistability in a narrow parameter regime which, however, lacks experimental support.
An analytical framework similar to that in Ref. [ 43] is, however, yet to be developed for the mycobacterial stringent response pathway studied in the paper.
In the present study, we have characterised quantatively the single cell promoter activity of three key genes in the stringent response pathway of the mycobacterial population M. smegmatis.
The response regulator MprA has an essential role in the stringent response pathway leading to persistence of mycobacteria under nutrient deprivation.
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